Receptor-type protein tyrosine phosphatases in cancer / 癌症
Chinese Journal of Cancer
;
(12): 61-69, 2015.
Article
in English
| WPRIM
| ID: wpr-349635
ABSTRACT
Protein tyrosine phosphatases (PTPs) play an important role in regulating cell signaling events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival, migration, and invasion. Receptor-type protein tyrosine phosphatases (PTPRs) are a subgroup of PTPs that share a transmembrane domain with resulting similarities in function and target specificity. In this review, we summarize genetic and epigenetic alterations including mutation, deletion, amplification, and promoter methylation of PTPRs in cancer and consider the consequences of PTPR alterations in different types of cancers. We also summarize recent developments using PTPRs as prognostic or predictive biomarkers and/or direct targets. Increased understanding of the role of PTPRs in cancer may provide opportunities to improve therapeutic approaches.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Cell Survival
/
Apoptosis
/
Cell Proliferation
/
Receptor-Like Protein Tyrosine Phosphatases
/
Genetics
/
Neoplasm Invasiveness
/
Neoplasms
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2015
Type:
Article
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