Detection, diagnosis and analysis of the first case of neonatal alloimmune thrombocytopenia purpura associated with anti-HPA-5b in China / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 399-402, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-349701
ABSTRACT
This study was aimed to investigate the detection and diagnosis of the neonatal alloimmune thrombocytopenia purpura (NAITP) caused by anti-HPA-5b antibody. The platelet count and clinical manifestation in the newborn were examined. The HPA-1-21bw genotypes of the newborn and her parents were detected by multiple-PCR and DNA sequencing. The HPA-specific antibody in the sera of newborn and her mother were detected and identified by flow cytometry (FCM) and monoclonal antibody-specific immobilization of platelet antigens (MAIPA). The results indicated that the clinical manifestations of the newborn were lighter. The HPA genotyping showed that the genotype of the newborn was HPA-5ab, while that of her mother and father were HPA-5aa and HPA-5ab, respectively. The antibody against the platelet of newborn's father existed in the newborn's mother sera. The HPA antibody of the mother was identified as anti-HPA-5b. It is concluded that the newborn with neonatal alloimmune thrombocytopenia purpura was caused by the antibody against HPA-5b.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
China
/
Purpura, Thrombocytopenic, Idiopathic
/
Antigens, Human Platelet
/
Diagnosis
/
Thrombocytopenia, Neonatal Alloimmune
/
Genetics
/
Genotype
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Female
/
Humans
/
Infant, Newborn
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2014
Type:
Article
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