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Expression and clinical significance of miR-21 in diffuse large B cell lymphoma / 中国实验血液学杂志
Article in Chinese | WPRIM | ID: wpr-349711
Responsible library: WPRO
ABSTRACT
This study was aimed to investigate the expression of microRNA-21 and its correlation with PTEN in diffuse large B cell lymphoma (DLBCL) paraffin-embedded tissues, and evaluate its potential relevance with clinical characteristics. The expression levels of miR-21 in 26 primary DLBCL and 10 normal lymph node tissue specimens were examined by real-time polymerase chain reaction. The expression of PTEN was detected by immunohistochemical staining. The results indicated that the expression of miR-21 was significantly higher in tumor tissues [6.586(1.10,38.22)] than that in normal tissues [0.791 (0.35,2.87)] (P < 0.05). Among 26 patients with DLBCL the expression of PTEN protein was positive in 6 patients (23%), and was negative in 20 patients (77%). In patients with DLBCL, the expression level of miR-21 was negatively correlated with the level of PTEN protein. The high expression of miR-21 was positively correlated with the level of serum LDH. The expression level of miR-21 in patients with Ann Arbor III-IV stage was obviously higher than that of patients with Ann Arbor I-II stage, but did not correlate with the subtype of patients in clinic (P > 0.05). It is concluded that the expression of miR-21 is high in DLBCL and its overexpression may be related with poor prognosis of DLCBL. These findings suggest that PTEN is possibly one of the targets of miR-21 in DLBCL.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Aged, 80 and over / Aged / Female / Humans / Male / Lymphoma, Large B-Cell, Diffuse / Adult / MicroRNAs / PTEN Phosphohydrolase Language: Chinese Journal: Journal of Experimental Hematology Year: 2014 Type: Article
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Aged, 80 and over / Aged / Female / Humans / Male / Lymphoma, Large B-Cell, Diffuse / Adult / MicroRNAs / PTEN Phosphohydrolase Language: Chinese Journal: Journal of Experimental Hematology Year: 2014 Type: Article