TCR-mediated signaling / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 532-536, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-350068
ABSTRACT
In recent years, major progress has been obtained in studying the early events in TCR-mediated signaling. c-Cb1 has been found to be a negative regulatory factor of the tyrosine kinases in ZAP-70/SyK family. The studies on LAT, SLP-76, ItK and Vav have shown their roles in the signal transduction of Ras and phospholipase Cx1 to Ca2+. Micro-glycolipid raft also plays important role in T cell activation. This minireview shows a brief introduction to the process of TCR-mediated signaling.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Receptors, Antigen, T-Cell
/
Signal Transduction
/
Proto-Oncogene Proteins
/
Ubiquitin-Protein Ligases
/
Allergy and Immunology
/
Proto-Oncogene Proteins c-cbl
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2002
Type:
Article
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