Action of miosis of 1% pilocarpine liposome in rabbits / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 343-345, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-350095
ABSTRACT
<p><b>OBJECTIVE</b>To compare the action of miosis of 1% pilocarpine liposome with 1% pilocarpine solution in rabbits.</p><p><b>METHODS</b>18 white rabbits were randomly divided into 3 groups. Test group received 1% pilocarpine liposome, positive control group received 1% pilocarpine solution, negative control group received liposome. Each eye drop instilled into left eye of rabbits and sterile saline solution instilled into right eye as control. The pupil diameter was measured at time intervals of beginning, 0.25, 0.5, 1, 2, 3, 4, 5, 7 hours.</p><p><b>RESULTS</b>The mean pupil diameter change of 3 groups in both eyes was not significant (P > 0.05) at beginning. The strongest action of miosis took place 0.25 h in positive control group and 0.5 h in test group after instillation. The dilation of pupil in both groups took place 1 h and 3 h, and the restoration of pupil in both groups took place at 5 h and 7 h. The mean pupil diameter of negative control group was not significant in seven hours.</p><p><b>CONCLUSIONS</b>The results suggest that 1% pilocarpine liposome improves the bioavailability and prolong the duration of its action.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Pilocarpine
/
Random Allocation
/
Pupil
/
Delayed-Action Preparations
/
Liposomes
/
Miotics
Limits:
Animals
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS