Review on anxiolytic effect of natural small-molecule phenols / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1557-1565, 2017.
Article
in Zh
| WPRIM
| ID: wpr-350148
Responsible library:
WPRO
ABSTRACT
Phenolic compounds have multiple bioactivities, such as anti-oxidant, anti-tumor, anti-bacterial, and anti-inflammatory activities. Recent literatures have demonstrated that flavonoids have a significant anti-anxiety effect on the central nervous system. In addition, studies showed that flavonoids acted as pro-drugs, which were transformed into smaller phenols through intestinal microflora. The small phenolic metabolites were crucial for the anxiolytic effects of these flavonoids, indicating that natural small-molecule phenols(NSMP) generally have anxiolytic activities. In this paper, the supporting evidences (before June 2016) from SciFinder database have been summarized. Furthermore, NSMPs were classified according to chemical structures; their anxiolytic effects, mechanisms, and the structure-activity relationships were also discussed.
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Index:
WPRIM
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2017
Type:
Article