Stress-induced growth-differentiation factor 15 plays an intriguing role in cardiovascular diseases / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1350-1354, 2013.
Article
in English
| WPRIM
| ID: wpr-350514
ABSTRACT
<p><b>OBJECTIVE</b>To provide an overview of the current knowledge of growth-differentiation factor 15 (GDF-15) in heart disease.</p><p><b>DATA SOURCES</b>To identify relevant publications, we searched PubMED database combining the textual terms of heart, cardiac, cardiovascular disease with GDF-15.</p><p><b>STUDY SELECTION</b>Well-controlled, relatively large-scale, retrospective studies as well as meaningful individual cases were all selected as materials.</p><p><b>RESULTS</b>GDF-15 is a distant member of the transforming growth factor-β cytokine superfamily. In myocardium, GDF-15 is weakly expressed under physiological conditions. However, its expression level is increased in response to pathological stress. Growing evidence indicate that elevated levels of GDF-15 is a promising prognostic biomarker in cardiovascular diseases. Moreover, GDF-15 exhibits the properties of endogenous anti-hypertrophy of cardiomyocytes and protecting the heart suffering from ischemia and reperfusion insult.</p><p><b>CONCLUSION</b>Ve GDF-15 may be a promising biomarker for evaluation and management of patient with cardiovascular diseases, and have potential protective properties on myocardium.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Stress, Physiological
/
Biomarkers
/
Cardiovascular Diseases
/
Growth Differentiation Factor 15
/
Metabolism
Type of study:
Observational study
/
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2013
Type:
Article
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