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Analysis of cytochrome P450 2E1 RsaI/PstI and DraI polymorphisms in workers exposed to benzene / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 595-597, 2015.
Article in Chinese | WPRIM | ID: wpr-350530
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the cytochrome P450 2E1 (CYP2E1) RsaI/PstI and DraI polymorphisms in workers exposed to benzene.</p><p><b>METHODS</b>A cross-sectional survey was carried out. A total of 71 workers exposed to benzene were included in observation group and the same number of people without occupational benzene exposure were included in control group. Blood samples from the two groups were collected and genotyping for CYP2E1 RsaI/PstI and DraI were conducted using the polymerase chain reaction-restriction fragment length polymorphism.</p><p><b>RESULTS</b>There were no significant differences in CYP2E1 DraI genotype and allele distributions between the observation group and the control group (χ² = 2.374, P > 0.05; χ² = 2.113, P > 0.05). Significant differences in CYP2E1 RsaI/PstI genotype and allele distributions between the two groups were observed (χ² = 9.129, P < 0.01; χ² = 6.028, P < 0.05).</p><p><b>CONCLUSION</b>Mutations at CYP2E1 RsaI/PstI can enhance the expression of CYP2E1 and this suggests individuals with the mutated gene have increased susceptibility to chronic benzene poisoning.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Poisoning / Polymorphism, Genetic / Benzene / Polymorphism, Restriction Fragment Length / Polymerase Chain Reaction / Cross-Sectional Studies / Cytochrome P-450 CYP2E1 / Genetic Predisposition to Disease / Alleles / Genetics Type of study: Observational study / Prevalence study / Risk factors Limits: Humans Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Poisoning / Polymorphism, Genetic / Benzene / Polymorphism, Restriction Fragment Length / Polymerase Chain Reaction / Cross-Sectional Studies / Cytochrome P-450 CYP2E1 / Genetic Predisposition to Disease / Alleles / Genetics Type of study: Observational study / Prevalence study / Risk factors Limits: Humans Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2015 Type: Article