Effects of sapindus saponins on inflammatory response mediated by Ang II/p38MAPK pathway and cardiac hypertrophy in spontaneously hypertensive rats / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1030-1035, 2013.
Article
in Zh
| WPRIM
| ID: wpr-350666
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of sapindus saponins on myocardial inflammation mediated by Ang II/ p38MAPK signal pathway and cardiac hypertrophy in spontaneously hypertensive rats. And also to explore the correlation of cardiac hypertrophy and inflammation.</p><p><b>METHOD</b>Thirty-two 16-week-old spontaneously hypertensive rats (SHR) were randomly divided into four groups, one with placebo as model group, one with captopril tablets (27 mg x kg(-1)) as positive control, one with low-dose sapindus saponins (27 mg x kg(-1)), one with high-dose (108 mg x kg(-1)). And another eight healthy Wistar-Kyoto strain (WKY) rats were used as the normal group. The animals were treated for eight weeks, and the indicators detected were as follows: (1) left ventricular mass index (LVMI); (2) the content of Ang II and hs-CRP in plasma were determined by ELISA; (3) the protein expression of AT1R and VEGF were determined by immunohistochemical method; (4) the protein expression of p-p38MAPK in myocardial cells was determined by Western blot.</p><p><b>RESULT</b>Sapindus saponins reduced LVMI, and blocked the expression level of Ang II, AT1R, p-p38MAPK, VEGF and hs-CRP in myocardial tissue. Vs the SHR model group, there were significant differences (P < 0.05 or P < 0.01).</p><p><b>CONCLUSION</b>Our findings suggested that sapindus saponins could inhibited cardiac hypertrophy, the possible mechanisms may be related to the inhibition on inflammatory response mediated by Ang II/p38MAPK pathway.</p>
Full text:
1
Index:
WPRIM
Main subject:
Rats, Inbred SHR
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Rats, Inbred WKY
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Saponins
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Angiotensin II
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Drugs, Chinese Herbal
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Chemistry
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Rats, Wistar
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Hypertrophy, Left Ventricular
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Sapindus
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P38 Mitogen-Activated Protein Kinases
Type of study:
Clinical_trials
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Prognostic_studies
Limits:
Animals
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Female
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Humans
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Male
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Type:
Article