Application of network analysis in diseases and drug studies / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 773-776, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-350688
ABSTRACT
A disease is rarely caused by a single virulence gene, but by an imbalanced regulatory network arising from dysfunction of multiple genes or their products. However, drugs intervene the occurrence and development of a disease by acting on multiple target points in the disease network and making a synergy effect on each target point, in order to achieve the therapeutic effect. Unlike traditional approaches focusing on a single molecule or pathway, network analysis with high-throughput data provides a new perspective for studying disease pathobiology and pharmacological mechanisms, and brings forth new ideas for multi-component and multi-target-point pharmacologic mechanisms of traditional Chinese medicines, in three aspects-establishment of relevant disease and drug network, network decomposition, and biological significant of sub-network.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Disease
/
Computational Biology
/
Drug Therapy
/
Medicine, Chinese Traditional
/
Methods
Type of study:
Diagnostic study
Limits:
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Type:
Article
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