Study on efficacy and mechanism of weiyangning pills against experimental gastric ulcer / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 736-739, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-350695
ABSTRACT
<p><b>OBJECTIVE</b>To study the efficacy and mechanism of Weiyangning pills against experimental gastric ulcer.</p><p><b>METHOD</b>The gastric ulcer model were established by acetic acid, water-immersion stress, aspirin induction, pyloric ligation in rats, in order to observe the effect of Weiyangning pills against experimental gastric ulcer and study its effect on the content of nitric oxide (NO) and epidermal growth factor (EGF), gastric mucosal blood flow, the content of PGE2, gastric secretion, gastric acid content and the activity of pepsin.</p><p><b>RESULT</b>Weiyangning pills markedly reduced index of gastric ulcers of various types, increased the content of NO, EGF, PGE2 and gastric mucosal blood flow, inhibited gastric secretion and gastric acid content, and decreased the activity of pepsin.</p><p><b>CONCLUSION</b>Weiyangning pills has a significant effect against experimental gastric ulcer, which is related to the reduction of gastric mucosa damage factors (gastric acid and pepsin) and the increase in gastric mucosa's function as a barrier and its recovery effects, such as NO, EGF, PGE2 and gastric mucosal blood flow.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Regional Blood Flow
/
Stomach Ulcer
/
Drugs, Chinese Herbal
/
Dinoprostone
/
Aspirin
/
Rats, Sprague-Dawley
/
Acetic Acid
/
Bodily Secretions
/
Therapeutic Uses
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2013
Type:
Article
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