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Simultaneous determination of ephedrine hydrochloride, D-pseudoephedrine and amygdalin in xiao'er pingchuan qutan granule by HPLC / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 687-690, 2013.
Article in Chinese | WPRIM | ID: wpr-350705
ABSTRACT
<p><b>OBJECTIVE</b>To establish an HPLC method for the determination of ephedrine hydrochloride, D-pseudo-ephedrine and amygdalin in Xiao'er Pingchuan Qutan granule.</p><p><b>METHOD</b>Pheny ether chromatographic column (4.6 mm x 250 mm, 5 microm) was adopted, with acetonitrile-0.1% phosphoric acid (containing 0.1% three ethylamine) (397) as the mobile phase. The UV detection wavelength was at 210 nm, with the flow rate of 1 mL x min(-1), and column temperature was at 35 degrees C.</p><p><b>RESULT</b>The linearity of ephedrine hydrochloride, D-pseudo-ephedrine and amygdalin ranged between 0.078 60-3.144 microg (r = 1.000 0), 0.103 4-2.068 microg (r = 0.999 7) and 0.430 5-3.157 microg (r = 0.999 8), respectively. Their average recoveries were 98.46% (RSD 1.1%), 103.0% (RSD 1.5%) and 97.15% (RSD 2.1%), respectively.</p><p><b>CONCLUSION</b>The method is simple, stable and reliable that it can be used to determine the content of ephedrine hydrochloride, D-pseudo-ephedrine and amygdalin in Xiao'er Pingchuan Qutan granule.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Time Factors / Drugs, Chinese Herbal / Linear Models / Chemistry / Reproducibility of Results / Chromatography, High Pressure Liquid / Ephedrine / Pseudoephedrine / Amygdalin Type of study: Prognostic study Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Time Factors / Drugs, Chinese Herbal / Linear Models / Chemistry / Reproducibility of Results / Chromatography, High Pressure Liquid / Ephedrine / Pseudoephedrine / Amygdalin Type of study: Prognostic study Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2013 Type: Article