Phosphatidylserine and male reproduction / 中华男科学杂志
National Journal of Andrology
; (12): 662-666, 2013.
Article
in Zh
| WPRIM
| ID: wpr-350840
Responsible library:
WPRO
ABSTRACT
Phosphatidylserine (PS) is an amphiphilic phospholipid ubiquitously present in the inside of the membrane of prokaryotic and eukaryotic cells. In mammalian cells, there are two synthetic pathways for PS that are different from those of bacterial biosynthesis. The translocation of sperm PS from the inner to the outer leaflet of the plasma membrane is considered to be associated with sperm apoptosis and male infertility. The level of PS externalization in human sperm is used as an indicator for the evaluation of sperm quality. Fast separation of PS-externalized sperm at the molecular level by flow cytometry or magnetic activated cell sorting can effectively improve the quality of sperm and the success rate of assisted reproductive technology. This paper reviews the structure properties, distribution, biological activity and synthesis of PS, as well as its association with male reproduction.
Full text:
1
Index:
WPRIM
Main subject:
Phosphatidylserines
/
Infertility, Male
/
Metabolism
Limits:
Animals
/
Humans
/
Male
Language:
Zh
Journal:
National Journal of Andrology
Year:
2013
Type:
Article