Molecular mechanisms of leupaxin involved in prostate carcinoma metastasis / 中华男科学杂志
National Journal of Andrology
;
(12): 555-558, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-350860
ABSTRACT
Leupaxin (LPXN) is a new member of the Paxillin superfamily, mainly located in focal adhesion plaques, involved in the transduction of multiple signaling pathways, and regulating the proliferation, adhesion and migration of tumor cells. In prostate cancer cells, LPXN is not only involved in the integrin signaling transduction pathway, regulating the proliferation, adhesion and migration of prostate cancer cells, but is also a new androgen receptor (AR) coactivator, regulating the transcription of nuclear AR effect genes, participating in AR signal transduction, and regulating the differentiation and invasion of prostate cancer cells. This review focuses on the molecular structure, special roles and molecular mechanisms of LPXN involved in prostatic carcinoma metastasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Phosphoproteins
/
Prostatic Neoplasms
/
Signal Transduction
/
Receptors, Androgen
/
Cell Adhesion Molecules
/
Genetics
/
Metabolism
/
Neoplasm Metastasis
Limits:
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS