Relationship between the expression of HBV mRNA in embryos and father-to-infant HBV transmission / 中华男科学杂志
National Journal of Andrology
;
(12): 429-433, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-350885
ABSTRACT
<p><b>OBJECTIVE</b>To investigate father-to-infant transmission of hepatitis B virus (HBV) by detecting HBV mRNA in the IVF embryos with paternal HBV infection.</p><p><b>METHODS</b>We collected 18 discarded IVF embryos (9 cases) with paternal chronic HBV infection, and detected HBV mRNA in the embryos by single-cell RT-PCR.</p><p><b>RESULTS</b>HBV mRNA positive signals were found in 1 of the 18 embryos with paternal serum HBV positive markers (5.6%), but no specific HBV mRNA signals were observed in the 84 embryos of the negative control group. Follow-up visits revealed no significant difference between the experimental and negative control groups either in the rate of clinical pregnancy (P > 0.05) or in that of early abortion (P > 0.05). The IVF embryo with paternal HBV mRNA positive signals was successfully implanted, but early abortion occurred. HBV infection was not transmitted to progeny in either of the two groups.</p><p><b>CONCLUSION</b>The positive results of HBV mRNA indicate that HBV can get into early-cleavage embryos through sperm and replicate there, which may be the main channel of father-to-infant transmission. HBV may interfere with the development of embryos, and even result in abortion and other adverse outcomes.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
RNA, Messenger
/
RNA, Viral
/
Fertilization in Vitro
/
Hepatitis B virus
/
Infectious Disease Transmission, Vertical
/
Embryo, Mammalian
/
Fathers
/
Genetics
/
Hepatitis B
Limits:
Adult
/
Female
/
Humans
/
Male
/
Pregnancy
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2013
Type:
Article
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