Effects of slenderstyle Acanthopanax root-bark on cyclooxygenase / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the effects of slenderstyle acanthopanax root-bark on cyclooxygenase in vivo and in vitro.</p><p><b>METHOD</b>Contents of 6-keto-PGF1alpha in bovine aorta endothelial cells, PGE2 in mouse abdominal macrophages, and 6-keto-PGF1alpha in rat stomach tissue were determined. The ulcer index in rat gastric mucosa was measured.</p><p><b>RESULT</b>COX-1 and COX-2 were inhibited by slenderstyle acanthopanax root-bark, and the inhibitive rate of COX-2 was higher than that of COX-1 at the same concentration. Necrotic injuries in health gastric mucosa were not produced, but the injuries previously induced by the ethanol worsened.</p><p><b>CONCLUSION</b>One of the antirheumatic mechanisms of slender-root-bark might probably be mediating through inhibition of cyclooxygenase. style acanthopanax</p>