Isolation and structural elucidation of a bioactive saponin from tubers of Bolbostemma paniculatum / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 213-217, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-350971
ABSTRACT
<p><b>OBJECTIVE</b>To study the bioactive constituents from tubers of Bolbostemma paniculatum.</p><p><b>METHOD</b>Compounds were isolated by extraction and partition as well as several-chromatographic techniques guided with Pyricularia oryzae bioassay method. Their structures were determined on the basis of spectral analysis and chemical evidence.</p><p><b>RESULT</b>Bisdesmoside (I) was isolated as active compound causing morphological abnormality of Pyncularia oryzae mycelia and elucidated as 3-0-alpha-L-arabinopyranosyl (1-->2)-beta-D-glucopyranosyl-bayogenin-28-O-beta-D-xylopyranosyl (1-->3)-alpha-L-rhamnopyranosyl (1-->2)-alpha-L-arabinopyranoside.</p><p><b>CONCLUSION</b>I is a new natural product and exhibited significant cytotoxicity against cancer cell lines K-562 and BEL-7402, but no hemolytic activity to rabbit erythrocytes.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Plants, Medicinal
/
Saponins
/
Biological Assay
/
Molecular Structure
/
Chemistry
/
Carcinoma, Hepatocellular
/
Cucurbitaceae
/
K562 Cells
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2006
Type:
Article
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