Studies on antitumor effects of podophyllotoxin nanoliposome / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 148-150, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-350985
ABSTRACT
<p><b>OBJECTIVE</b>To compare the antitumor effects of the podophyllotoxin nanoliposome and the suspensions of podophyllotoxin in bearing-tumor mice.</p><p><b>METHOD</b>The experimental mice were inoculated by suspension liquid of tumor cell in axillary region near the forelimb, 0.2 mL each. The mice had been randomly divided into 8 groups 24 h latter. The podophyllotoxin nanoliposome, suspension liquid of the podophyllotoxin, CX or NS was given to each group respectively. Except CX was given by celiac injection once, the other groups were injected every 4 days for three times. The mice were killed by hauling necks on the twelfth day after treatment, the tumor was weighed and the inhibitory rate was calculated.</p><p><b>RESULT</b>When the dosage of podophyllotoxin nanoliposome and the suspensions of podophyllotoxin reached 5.0 mg x kg(-1), the rate of inhibiting tumor were 52.37% and 38.25% to the H22 liver cancer of mice respectively.</p><p><b>CONCLUSION</b>Podophyllotoxin nanoliposome and the suspensions of podophyllotoxin have the effect in anti-liver cancer. And podophyllotoxin nanoliposome have stronger inhibitory rate compared with suspension liquid of the podophyllotoxin in same dose.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Podophyllotoxin
/
Random Allocation
/
Carcinoma, Hepatocellular
/
Cell Line, Tumor
/
Nanostructures
/
Liposomes
/
Liver Neoplasms
/
Neoplasm Transplantation
Type of study:
Controlled clinical trial
Limits:
Animals
/
Female
/
Humans
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2006
Type:
Article
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