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Change of iodine load and thyroid homeostasis induced by ammonium perchlorate in rats / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 672-678, 2014.
Article in English | WPRIM | ID: wpr-351020
ABSTRACT
Ammonium perchlorate (AP), mainly used as solid propellants, was reported to interfere with homeostasis via competitive inhibition of iodide uptake. However, detailed mechanisms remain to be elucidated. In this study, AP was administered at 0, 130, 260 and 520 mg/kg every day to 24 male SD rats for 13 weeks. The concentrations of iodine in urine, serum thyroid hormones levels, total iodine, relative iodine and total protein, and malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) activity in thyroid tissues were measured, respectively. Our results showed that high-dose perchlorate induced a significant increase in urinary iodine and serum thyroid stimulating hormone (TSH), with a decrease of total iodine and relative iodine content. Meanwhile, free thyroxine (FT4) was decreased and CAT activity was remarkably increased. Particularly, the CAT activity was increased in a dose-dependent manner. These results suggested that CAT might be enhanced to promote the synthesis of iodine, resulting in elevated urinary iodine level. Furthermore, these findings suggested that iodine in the urine and CAT activity in the thyroid might be used as biomarkers for exposure to AP, associated with thyroid hormone indicators such as TSH, FT4.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Superoxide Dismutase / Thyroid Gland / Thyroxine / Triiodothyronine / Urine / Blood / Radioimmunoassay / Thyrotropin / Catalase Limits: Animals Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Superoxide Dismutase / Thyroid Gland / Thyroxine / Triiodothyronine / Urine / Blood / Radioimmunoassay / Thyrotropin / Catalase Limits: Animals Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2014 Type: Article