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Up-regulated expression of Tim-3/Gal-9 at maternal-fetal interface in pregnant woman with recurrent spontaneous abortion / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences) ; (6): 586-590, 2014.
Article in English | WPRIM | ID: wpr-351035
ABSTRACT
The relationship between T cell immunoglobulin domain and mucin domain protein 3 (Tim-3)/Galectin (Gal)-9 pathway and recurrent spontaneous abortion (RSA) was studied. Thirty-one pregnant women with RSA and 27 normal early gravidas were investigated to detect the levels of Tim-3 and Gal-9 in villi and deciduas by Western blotting. Meanwhile, the concentration of interleukin (IL)-4 and IL-12 in peripheral blood plasma was determined by ELISA in 25 healthy fertile non-pregnant controls, the normal early gravidas and pregnant women with RSA mentioned above, respectively. It was found that the relative expression levels of Tim-3 and Gal-9 in villi and deciduas were significantly increased in pregnant women with RSA as compared with those in the normal early gravidas. The concentration of IL-4 in peripheral blood plasma of pregnant women with RSA was lower than that of the normal early gravidas (P<0.05) and healthy fertile non-pregnant controls (P<0.05), but that of IL-2 in pregnant women with RSA was significantly higher than that of the normal early gravidas (P<0.05) and healthy fertile non-pregnant controls (P<0.05). It was suggested that the overexpression of Tim-3/Gal-9 pathway may be related to the pathogenesis of RSA.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pregnancy Proteins / Blood / Up-Regulation / Abortion, Spontaneous / Chorionic Villi / Interleukin-4 / Interleukin-12 / Galectins / Hepatitis A Virus Cellular Receptor 2 Limits: Adolescent / Adult / Female / Humans / Pregnancy Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pregnancy Proteins / Blood / Up-Regulation / Abortion, Spontaneous / Chorionic Villi / Interleukin-4 / Interleukin-12 / Galectins / Hepatitis A Virus Cellular Receptor 2 Limits: Adolescent / Adult / Female / Humans / Pregnancy Language: English Journal: Journal of Huazhong University of Science and Technology (Medical Sciences) Year: 2014 Type: Article