Clinical observation of injection of dexmedetomidine in anaesthesia for esophageal cancer operation / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 495-497, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-351119
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of administration of dexmedetomidine in anaesthesia for esophageal cancer operation.</p><p><b>METHODS</b>100 patients (ASAI-II) who were undergoing to esophageal cancer operation were randomly divided into control group (group A) and dexmedetomidine group (group B) (n = 50). The scheme of induction and maintenance of aesthesia of the two groups were identical. Patients in group B administered dexmedetomidine at a dose of 1 microg/kg over 10 min and patients in group A were given a placebo infusion of normal saline. Patients in group B administered dexmedetomidine at a dose of 0.4 microg/(kg x h) was injected and stoped at 30 min by the end of operation. Mean artery pressure (MAP) and heart rate (HR) were detected before induction (T0), induction (T1), 1 min after extubation (T2), 5 min after extubation (T3) and 10 min after extubation (T4) Propofol comsumption, fentanlyl comsumption, and side effects were recorded as well.</p><p><b>RESULTS</b>The results showed that MAP and HR (T0, T1, T2, T3, T4) in group B were significantly different from those in group A which fluctuated more markedly (P < 0.05). Propofol comsumption in group A was much more than that in group B (P < 0.05). Incidence of pharynx and larynx ache and restlessness were higher in group A than those in group B (P < 0.05).</p><p><b>CONCLUSION</b>Dexmedetomidine could effectively reduce the cardiovascular response to incubation and extubation in esophageal cancer operation patients. Propofol comsumption, fentanlyl comsumption and side effects were reduceed as well.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
General Surgery
/
Esophageal Neoplasms
/
Propofol
/
Fentanyl
/
Anesthetics, Intravenous
/
Analgesics, Non-Narcotic
/
Dexmedetomidine
/
Adjuvants, Anesthesia
Type of study:
Controlled clinical trial
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2011
Type:
Article
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