Lipid peroxidation and biomechanical properties of artery in hyperlipemia rats after treating with tetrahydrobiopterin / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 461-464, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-351128
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of the level of lipid peroxidation and biomechanical properties after chronic treating with tetrahydrobiopterin (BH4) in thoracic aorta of hyperlipemia (HL) rats.</p><p><b>METHODS</b>HL rats were given BH4 chronically. The opening angle in the zero-stress state and the relationship between pressure and diameter (P-D) of mesenteric artery were measured by computer image 8, 16, and 24 week-old respectively.</p><p><b>RESULTS</b>Treating with BH4 chronically from 8 week-old in HL rats, there was a significant increase in the zero-stress state of opening angle of thoracic aorta. The P-D curve of mesenteric artery moved upward.</p><p><b>CONCLUSION</b>Treating with BH4 prevented the structure and function of artery from abnormal changing, and attenuated lipid peroxidation in HL rats.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aorta, Thoracic
/
Biomechanical Phenomena
/
Biopterin
/
Lipid Peroxidation
/
Rats, Wistar
/
Therapeutic Uses
/
Drug Therapy
/
Hyperlipidemias
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2011
Type:
Article
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