Study on effect of oligochitosan in promoting intestinal absorption of protoberberine alkaloids in extracts from Corydalis saxicola total alkaloids / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1812-1816, 2015.
Article
in Zh
| WPRIM
| ID: wpr-351259
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of oligochitosan in promoting intestinal absorption of protoberberine alkaloids in extracts from Corydalis saxicola total alkaloids.</p><p><b>METHOD</b>The in vitro single-pass intestinal perfusion model in rats was established to study the changes in absorption kinetic parameters of dehydrocavidine, berberine hydrochloride and palmatine chloride in C. saxicola total alkaloids after the addition of different concentrations oligochitosan and evaluate the effect of oligochitosan in promoting intestinal absorption of the drugs.</p><p><b>RESULT</b>The concentration of oligochitosan had different effects on the absorption rate constant (Ka) and apparent permeability coefficient (Peff) of the three active component in rat intestines. Ka and Peff in 0.5% oligochitosan group significantly increased, indicating a stronger effect in promoting the absorption.</p><p><b>CONCLUSION</b>Oligochitosan has a certain effect in promoting the intestinal absorptions of protoberberine alkaloids in C. saxicola total alkaloids.</p>
Full text:
1
Index:
WPRIM
Main subject:
Berberine Alkaloids
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Drugs, Chinese Herbal
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Pharmacokinetics
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Chemistry
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Chitin
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Rats, Sprague-Dawley
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Corydalis
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Intestinal Absorption
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Intestines
/
Metabolism
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2015
Type:
Article