Ethyl acetate-soluble chemical constituents from branch of Hypericum petiolulatum / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1755-1758, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-351270
ABSTRACT
The stems and branches of Hypericum petiolulatum were extracted by alcohol and liquid-liquid extraction. Seven furofuran lignans were isolated from the ethyl acetate fraction of ethanol extract of H. petiolulatum by using silica gelchromatography, Sephadex LH-20 chromatography, medium-pressure liquid chromatography and preparative HPLC. Their structures were identified by the spectroscopic methods as pinoresinol (1), medioresinol (2), 8-acetoxypinoresinol (3), epipinoresinol (4), (+)-syringaresinol (5), (+)-1-hydroxysyringaresinol (6) and erythro-buddlenolE (7). All the isolates were firstly found in H. petiolulatum. In the bioassay, compound 7 showed remarkable antioxidative activity inhibiting Fe(+2)-cystine induced rat liver microsomal lipid peroxidation with inhibitory rate 38% at a concentration of 1 x 10(-6) mol · L(-1) (positive control Vit E with the inhibitory rate of 35% at the same concentration).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Microsomes, Liver
/
Drugs, Chinese Herbal
/
Lipid Peroxidation
/
Molecular Structure
/
Chemistry
/
Plant Stems
/
Oxidative Stress
/
Hypericum
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2015
Type:
Article
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