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Ethyl acetate-soluble chemical constituents from branch of Hypericum petiolulatum / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1755-1758, 2015.
Article in Chinese | WPRIM | ID: wpr-351270
ABSTRACT
The stems and branches of Hypericum petiolulatum were extracted by alcohol and liquid-liquid extraction. Seven furofuran lignans were isolated from the ethyl acetate fraction of ethanol extract of H. petiolulatum by using silica gelchromatography, Sephadex LH-20 chromatography, medium-pressure liquid chromatography and preparative HPLC. Their structures were identified by the spectroscopic methods as pinoresinol (1), medioresinol (2), 8-acetoxypinoresinol (3), epipinoresinol (4), (+)-syringaresinol (5), (+)-1-hydroxysyringaresinol (6) and erythro-buddlenolE (7). All the isolates were firstly found in H. petiolulatum. In the bioassay, compound 7 showed remarkable antioxidative activity inhibiting Fe(+2)-cystine induced rat liver microsomal lipid peroxidation with inhibitory rate 38% at a concentration of 1 x 10(-6) mol · L(-1) (positive control Vit E with the inhibitory rate of 35% at the same concentration).
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Microsomes, Liver / Drugs, Chinese Herbal / Lipid Peroxidation / Molecular Structure / Chemistry / Plant Stems / Oxidative Stress / Hypericum / Metabolism Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Microsomes, Liver / Drugs, Chinese Herbal / Lipid Peroxidation / Molecular Structure / Chemistry / Plant Stems / Oxidative Stress / Hypericum / Metabolism Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2015 Type: Article