Study on porous starch as solid dispersion carrier of total Epimedium flavonoids / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1723-1726, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-351277
ABSTRACT
In order to evaluate the characteristic of porous starch (PS) as the solid dispersions carrier of the total Epimedium flavonoids (TEF), the PS was used. The dissolution of icariin was selected as an indicator to analyze the differences of dissolution between TEF and its solid dispersion. TEF was characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and X-ray powder diffraction (XRD). Solid dispersion was irregular block and no powder characteristics of TEF and PS could be seen in SEM, DSC and XRD analysis suggested that TEF may be present in solid dispersion as amorphous substance. The dissolution rate of icariin has been improved significantly when the proportion of TEF and PS was 12. PS as a traditional solid dispersion carrier is worthy of further study.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Solubility
/
Starch
/
X-Ray Diffraction
/
Flavonoids
/
Calorimetry, Differential Scanning
/
Drugs, Chinese Herbal
/
Chemistry
/
Chemistry, Pharmaceutical
/
Porosity
/
Epimedium
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2015
Type:
Article
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