Diagnostic values of prealbumin and retinol-binding protein for liver damage caused by different degrees of neonatal asphyxia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 337-341, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-351349
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the diagnostic values of prealbumin (PAB) and retinol-binding protein (RBP) for liver damage caused by mild or severe asphyxia.</p><p><b>METHODS</b>A retrospective analysis was performed on 185 neonates (including 84 premature infants and 101 full-term infants) with asphyxia. Based on the Apgar score, they were divided into two groups mild asphyxia group (n=150) and severe asphyxia group (n=35). The levels of PAB, RBP, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were measured and compared. Their diagnostic values for liver damage were evaluated by ROC curve analysis.</p><p><b>RESULTS</b>The premature infants in the severe asphyxia group had significantly higher AST level and significantly lower levels of PAB and RBP than those in the mild asphyxia group (P<0.05). The full-term infants in the severe asphyxia group had a significantly lower PAB level than those in the mild asphyxia group (P<0.05). After treatment, the PAB level was significantly improved in the premature infants in the severe asphyxia group and in the full-term infants in both mild and severe asphyxia group (P<0.05). The full-term infants in the mild asphyxia groups also showed a significant improvement in AST level (P<0.05). The ROC curve analysis showed that PAB had a good sensitivity and specificity for identifying liver damage caused by mild or severe asphyxia in full-term and preterm infants.</p><p><b>CONCLUSIONS</b>PAB can be used as an indicator of liver damage caused by asphyxia in neonates, and can be used to assess the degree of asphyxia.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aspartate Aminotransferases
/
Asphyxia Neonatorum
/
Blood
/
Prealbumin
/
Retinol-Binding Proteins
/
Serum Albumin
/
Diagnosis
/
Liver Diseases
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
/
Infant, Newborn
Language:
Chinese
Journal:
Chinese Journal of Contemporary Pediatrics
Year:
2017
Type:
Article
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