The diagnosis and treatment of primary biliary cirrhosis / 대한간학회지
The Korean Journal of Hepatology
;
: 173-179, 2011.
Article
in English
| WPRIM
| ID: wpr-35142
ABSTRACT
Primary biliary cirrhosis (PBC) is a slowly progressive cholestatic liver disease of autoimmune etiology. The initial presentation of PBC is various from asymptomatic, abnormal liver biochemical tests to overt cirrhosis. The diagnosis of PBC is based on cholestatic biochemical liver tests, presence of antimitochondrial antibody and histologic findings of nonsuppurative destructive cholangitis. Although the diagnosis is straightforward, it could be underdiagnosed because of its asymptomatic presentation, or underrecognition of the disease. UDCA in a dose of 13-15 mg/kg is the widely approved therapy which can improve the prognosis of patients with PBC. However, one-third of patients does not respond to UDCA therapy and may require liver transplantation. Every effort to diagnose PBC in earlier stage and to develop new therapeutic drugs and clinical trials should be made.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoantibodies
/
Ursodeoxycholic Acid
/
Cholagogues and Choleretics
/
Autoimmunity
/
Liver Transplantation
/
Liver Cirrhosis, Biliary
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
The Korean Journal of Hepatology
Year:
2011
Type:
Article
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