Advances in efficacy and security of expanded mesenchymal stem cells in vitro / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 1629-1635, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-351555
ABSTRACT
The multipotent differentiation and immunosuppression capability of mesenchymal stem cells (MSCs) make it attractive source for stem cell therapy to treat serious diseases, including neural system diseases and immune disorders. For large scale clinical applications, MSCs have to be expanded to produce sufficient quantity for multiple treatments. While conventional passaging is not appropriate for such a task, bioreactor can be used to expand MSCs more efficiently. Yet the efficacy and biosafety of expanded MSCs must be properly assessed before the expanded MSCs can be implanted. This review presented state-of-the-art in expanding MSCs focusing on the progress on the assessment of the efficacy and biosafety of in vitro expanded MSCs. Current obstacles were discussed and future research directions were outlined.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cell Differentiation
/
Cells, Cultured
/
Colony-Forming Units Assay
/
Bioreactors
/
Cell Biology
/
Mesenchymal Stem Cell Transplantation
/
Cell Proliferation
/
Mesenchymal Stem Cells
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2010
Type:
Article
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