Clinical significance and expression of the inflammatory cytokines (IL-1, IL-2, IL-6 and IL-10) in blood serum of the patients after total hip replacement / 中国骨伤
China Journal of Orthopaedics and Traumatology
;
(12): 463-465, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-351705
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the changes in the expressions of the inflammatory cytokines (IL-1, IL-2, IL-6 and IL-10) in blood serum of the patients after total hip replacement (THR).</p><p><b>METHODS</b>From February 2010 to June 2010, thirty patients undergone primary total hip arthroplasty in one side including 18 male and 12 female with the mean age of (58.4 +/- 6.6) years (ranged from 52 to 70 years). Twenty patients were Ficat II type,and 10 patients were Ficat III type. The contents of IL-1, IL-2, IL-6 and IL-10 in blood serum were detected on the day before operation and 1 to 3 days after operation respectively by ELISA. At the same time, the content of C reactive protein was also detected, and the results were statistically analyzed.</p><p><b>RESULTS</b>The contents of IL-1, IL-6 and IL-10 in the serum of patients at the first day after THR were significantly higher than those before operation (t = 2.62, 3.51, 2.21, P < 0.05), and reached the peak at 1 to 3 days after operations, then subsequently decreased. However, the content of IL-2 in the serum of patients after operation was obvious lower (t = 2.16, P < 0.05),and recovered to normal level gradually.</p><p><b>CONCLUSION</b>It is the key time of treatment at 1 to 3 days after THR. Monitoring IL-1, IL-2, IL-6 and IL-10 after operation in time, and monitoring life sign at the same time could sensitively observe the effect of treatment and forecast the trend of diseases in patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Interleukins
/
Interleukin-6
/
Interleukin-1
/
Interleukin-2
/
Interleukin-10
/
Arthroplasty, Replacement, Hip
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Orthopaedics and Traumatology
Year:
2011
Type:
Article
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