Protective effect of Uncaria rhynchophylla total alkaloids pretreatment on hippocampal neurons after acute hypoxia / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 763-765, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-351761
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Uncaria rhynchophylla total alkaloids (RTA) pretreatment on the voltage-gated sodium currents of the rat hippocampal neurons after acute hypoxia.</p><p><b>METHOD</b>Primary cultured hippocampal neurons were divided into RTA pre-treated and non-pretreated groups. Patch clamp whole-cell recording was used to compare the voltage-gated sodium current amplitude and threshold with those before hypoxia.</p><p><b>RESULT</b>After acute hypoxia, sodium current amplitude was significantly decreased and its threshold was upside. RTA pretreatment could inhibit the reduction of sodium current amplitude.</p><p><b>CONCLUSION</b>RTA pretreatment alleviates the acute hypoxia-induced change of sodium currents, which may be one of the mechanisms for protective effect of RTA on cells.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Plants, Medicinal
/
Potassium Channels
/
Sodium Channels
/
Cell Hypoxia
/
Cells, Cultured
/
Chemistry
/
Rats, Wistar
/
Neuroprotective Agents
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2006
Type:
Article
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