The role of connexin 43 gene in acupuncture analgesia / 中国针灸
Chinese Acupuncture & Moxibustion
; (12): 195-198, 2007.
Article
in Zh
| WPRIM
| ID: wpr-351907
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the possible relationship between the analgesic effect of acupuncture and connexin 43.</p><p><b>METHODS</b>Connexin 43 gene knock-out mice were divided into 4 groups: a wide type (WT) control group, a WT acupuncture group, a heterozygous (HT) control group and HT acupuncture group. Hot-plate test and writhing response induced by acetic acid were used for investigating the analgesic effect of acupuncture.</p><p><b>RESULTS</b>There was no significant difference in the basic pain threshold value between HT and WT mice (P > 0.05). Acupuncture could significantly increase the pain threshold value, prolong the latency period of writhing body and decrease the number of writhing body as compared with pre-acupuncture in WT and HT mice (P < 0.01 or P < 0.05). The pain threshold, latency period of writhing and number of writhing body in HT mice were less than WT mice post-acupuncture (P < 0.05).</p><p><b>CONCLUSION</b>Connexin 43 gene knock-out might partially inhibit the analgesic effect of acupuncture, suggesting that connexin 43 is possibly related with meridians and the effect of acupuncture.</p>
Full text:
1
Index:
WPRIM
Main subject:
Physiology
/
Acupuncture Analgesia
/
Pain Threshold
/
Gap Junctions
/
Connexin 43
/
Genetics
Limits:
Animals
Language:
Zh
Journal:
Chinese Acupuncture & Moxibustion
Year:
2007
Type:
Article