The relationship between the CT signs and p53 abnormal expression in peripheral lung cancer / 中国肺癌杂志

ABSTRACT

<p><b>BACKGROUND</b>To evaluate the relationship between the CT signs and p53 protein abnormal expression in peripheral lung cancer.</p><p><b>METHODS</b>Fifty-two patients with pulmonary masses underwent CT scanning before operation. Immunohistochemistry was used to detect p53 protein expression in pulmonary specimens obtained by operation.</p><p><b>RESULTS</b>There were significant differences among p53 protein expression and differentiation of lung cancer cell, size of the cancer, tumor appearance, pleura excavation and lymphatic metastasis.</p><p><b>CONCLUSIONS</b>p53 gene mutation indicates the biological behavior of lung cancer and might influence the morphological feature of lung cancer, which remarkably relates to CT signs of lung cancer.</p>