Clinical studies on expressions of Fas and mdr-1 in acute leukemia and their correlations / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 411-415, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-352052
ABSTRACT
To explore the Fas and mdr-1 expression and their correlation in multidrug resistance (MDR), Fas and mdr-1 expressions of bone marrow from 59 patients with newly diagnosed AL before therapy and after complete remission were detected by direct immunofluorescence with flow cytometry and semi-quantitative RT-PCR, respectively. The results showed that in newly diagnosed AL patients, Fas expression in AML was higher than in ALL (P < 0.05), mdr-1 expression in AML and ALL had no difference (P > 0.05), the expressions of Fas and mdr-1 had correlation (r = -0.282, P < 0.05) in AL; the results of simple-variable and multivariable COX survival factor model analysis suggested that Fas and mdr-1 expressions were prognostic factors for the effect of therapy and survival. Log rank test, comparing the groups of Fas(+) with Fas(-), mdr-1(+) with mdr-1(-), demonstrated that the CR rates and median remission time of every two groups had significant difference. It is concluded that in AL, Fas and mdr-1 expressions have high correlation with the effect of treatment, Fas expression probably is one of the favorable prognostic factors, mdr-1 is an unfavorable prognostic and less effective factor.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Leukemia, Myeloid, Acute
/
Mortality
/
Drug Resistance, Multiple
/
Drug Resistance, Neoplasm
/
Fas Receptor
/
Genes, MDR
/
Drug Therapy
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Metabolism
Type of study:
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2004
Type:
Article
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