Progress of studies on enhancing efficiency of gene transfection into hematopoietic cells with the adenoviral vector--review / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 383-386, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-352058
ABSTRACT
Recombinant adenoviral vectors have been widely applied for the basic research and clinical trials of gene therapy. However, the inability of adenovirus to infect hematopoietic cells which lack the specific adenovirus receptors-coxsackie virus and adenovirus receptor (CAR) represents an important limitation in therapeutic applications. This limitation may be overcome by several approaches including modification of adenovirus vector and improvement of the susceptibility of hematopoietic cells. The current progresses in this field were summarized.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Receptors, Virus
/
Hematopoietic Stem Cells
/
Transfection
/
Genetic Therapy
/
Adenoviridae
/
Coxsackie and Adenovirus Receptor-Like Membrane Protein
/
Genetics
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2004
Type:
Article
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