Unrelated HLA-matched donor marrow transplantation for one case of myelodysplastic syndrome / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 378-380, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-352060
ABSTRACT
To explore feasibility and efficacy of unrelated HLA matched donor marrow transplantation in treatment of myelodysplastic syndrome, one case (male, 31 years old) of myelodysplastic syndrome-refractory cytopenia with multilineage dysplasia (MDS-RCMD) has been received unrelated HLA-matched donor transplantation. Busulfan, cyclophosphamide, Ara-C, MeCCNU and antithymocyte globulin (ATG) were used for preparative regimen. Mycophenolate mofetile, cyclosporin A and short-term methotrexate were used for graft-versus-host disease prophylaxis. The results showed that neutrophil of > 0.5 x 10(9)/L, platelet of 58 x 10(9)/L and hemoglobin of 114 g/L were observed at 10, 20 days and 3 months respectively post transplantation. Disease-free survival without GVHD was 9 months. In conclusion, unrelated HLA matched donor marrow transplantation is an effective approach for treatment of patients with MDS.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Myelodysplastic Syndromes
/
Histocompatibility Testing
/
Follow-Up Studies
/
Bone Marrow Transplantation
/
Graft vs Host Disease
/
Hematopoiesis
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS