Effect of ligustrazine on the expression of LFA-1 and ICAM-1 in bone marrow transplantation recipient mice / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 174-178, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-352104
ABSTRACT
The objective of study was to investigate the effect of ligustrazine on the expression of LFA-1 and ICAM-1 in bone marrow and the mechanism of hematopoietic reconstitution after bone marrow transplantation (BMT). The 150 mice were randomly divided into 3 groups normal group, saline group and ligustrazine group. The normal group was not treated. The saline group was given normal saline (0.2 ml/mouse, twice a day) through gastric tube, while the ligustrazine group was given ligustrazine (0.2 ml/mouse, twice a day) through gastric tube. At days 7, 14, 21 and 28 after BMT, the survival rate, colony forming unit of spleen (CFU-S), peripheral blood cells, bone marrow mononuclear cells (BMMNC), histologic changes of bone marrow, as well as the expression level of LFA-1 and ICAM-1 were observed. The results showed that in ligustrazine group CFU-S counts on day 10 and survival rate, WBC and Plt amount in peripheral blood, BMMNC counts, hematopoietic tissue volume as well as the expression level of LFA-1 at 7, 14, 21, 28 days after BMT were higher than in saline group (P < 0.01 or P < 0.05). However, mature RBC volume and expression level of ICAM-1 were lower than in the saline group (P < 0.01 or P < 0.05). Furthermore, fat tissue volume was higher at 7 and 14 days (P < 0.01) and was lower at 21 and 28 days (P < 0.01) after BMT than in the saline group. It is concluded that ligustrazine could improve bone marrow microenvironment and promote hematopoietic reconstitution.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Pyrazines
/
Blood Cell Count
/
Bone Marrow Examination
/
Lymphocyte Function-Associated Antigen-1
/
Bone Marrow Transplantation
/
Intercellular Adhesion Molecule-1
/
Mice, Inbred BALB C
Limits:
Animals
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2004
Type:
Article
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