Characterization of collagen/polyvinyl alcohol complex membrane crosslinked by UV-riboflavin / 生物医学工程学杂志

ABSTRACT

The objective of this investigation was to study the characteristics and biocompatibility of collagen/polyvinyl alcohol (PVA) membrane crosslinked by UV-riboflavin. Membranes that were made into complex ones with different mass ratios of collagen to PVA (11 and 21) were synthesized, and crosslinked with UV-riboflavin. The surface characteristics were analyzed using the omnipotent materials instrument, IR, SEM, water absorption test, gas permeability test, and degradation test, respectively. The biocompatibility of membrane complex and rat bone marrow mesenchymal stem cells (BMSCs) was evaluated after 7 d and 14 d, respectively. The collagen/PVA complex membranes showed good homogeneity, mechanical property, degradation ratio, water absorption, gas permeability, etc. The biocompatibility of the collagen/PVA (21) complex membrane crosslinked with UV-Riboflavin was higher than that of without crosslinking and collagen/PVA (11) membrane. It could be well concluded that collagen/PVA complex membranes crosslinked with UV-riboflavin would have a potential application in biomedicine.