Study of the preparation of silk fibroin gel and its morphology as drug release matrix in vitro and in vivo / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 794-811, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-352164
ABSTRACT
Silk fibroin (SF)/sodium alginate (SA) hydrogels can be used as drug injection materials. Homogenate was prepared by centrifugation of the pig myocardial extracellular matrix (PMM) and its modification of SF gel material. This paper observes and compares the different components SF, SF/SA, SF/SA/PMM to illustrate the SF/SA/PMM ternary material as a drug delivery composition material. This ternary material can shorten the gel time, and can make the gel form to be maintained better. Meanwhile, it makes the internal structure of the gel looser so that the hole wall becomes thinner and more conducive to the drug release. In addition, it has good biocompatibility proved by pathological analysis, and is able to enhance the mesenchymal stem cells growth activity, which has great significance in carrying out drug control release.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Swine
/
Tissue Extracts
/
Biocompatible Materials
/
Drug Carriers
/
Chemistry
/
Hydrogels
/
Glucuronic Acid
/
Delayed-Action Preparations
/
Alginates
/
Extracellular Matrix
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2013
Type:
Article
Similar
MEDLINE
...
LILACS
LIS