The effects of early escharectomy on resting energy expenditure in the severely burned patients / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 37-39, 2004.
Article
in Chinese
| WPRIM
| ID: wpr-352238
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of early escharectomy on resting energy expenditure (REE) in severely burned patients dynamically with the metabolic monitoring and diagnostic system.</p><p><b>METHODS</b>Fifty-six adult male patients with severe burns were divided into early escharectomy (group A, n = 39, escharectomy within 5 PBDs) and non-early escharectomy (group B, n = 17, escharectomy after 5 PBDs) groups. The wounds of full thickness and deep partial thickness burn in the two groups were all excised and covered with allogeneic skin and autologous micro-skin in the first operation. The changes in REE were observed dynamically at the bedside of the patients with the metabolic monitoring and diagnostic system. The plasma contents of IL-6, IL-8, TNF-alpha and LPS from 9 patients in group A and 7 in group B were also determined dynamically.</p><p><b>RESULTS</b>All patients survived. The REE in both groups was elevated markedly, but REE in group A was lower compared with group B before and after escharectomy within 14 days. (P < 0.05). The plasma level of IL-6, IL-8, TNF-alpha and LPS in group A were obviously lower than those in group B (P < 0.05).</p><p><b>CONCLUSION</b>The hypermetabolic response of burn patients with severe burns could be lowered by early escharectomy, and it seemed to be related to the decrease of the release of proinflammatory mediators.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Care
/
General Surgery
/
Time Factors
/
Basal Metabolism
/
Blood
/
Burns
/
Lipopolysaccharides
/
Interleukin-8
/
Interleukin-6
/
Tumor Necrosis Factor-alpha
Type of study:
Health economic evaluation
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Burns
Year:
2004
Type:
Article
Similar
MEDLINE
...
LILACS
LIS