Molecular mechanism of the sensitivity of myocardial cell injury after severe hypoxia / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 134-136, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-352303
ABSTRACT
<p><b>OBJECTIVE</b>To explore the molecular mechanism of the sensitivity of myocardial cell injury after severe hypoxia.</p><p><b>METHODS</b>Differential expression of the genes in rat myocardium and skeletal muscles after severe hypoxia for 6 hours was determined by DNA chip containing 4096 mice genes.</p><p><b>RESULTS</b>There were high expressions of 125 genes in skeletal muscles and 111 genes in myocardial cells after 6 hours of severe hypoxia. Among them, high expression genes in myocardial cells included those encoding apoptosis activator Mtd, complement C3, vascular cell adhesion molecule-1, integrin beta subunit and lipopolysaccharide binding proteins (LBP).</p><p><b>CONCLUSION</b>Activation of apoptosis of myocardial cells and inflammatory mediators played important roles in myocardial cell injury after 6-hour severe hypoxia.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Complement C3
/
RNA, Messenger
/
Cells, Cultured
/
Muscle, Skeletal
/
Vascular Cell Adhesion Molecule-1
/
Proto-Oncogene Proteins c-bcl-2
/
Oligonucleotide Array Sequence Analysis
/
Gene Expression Profiling
/
Myocytes, Cardiac
Type of study:
Diagnostic study
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Burns
Year:
2003
Type:
Article
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