Allele polymorphisms of interleukin-10 and hepatitis B, C virus infection / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1338-1344, 2010.
Article
in English
| WPRIM
| ID: wpr-352563
ABSTRACT
<p><b>BACKGROUND</b>Interleukin 10 (IL-10) is an important cytokine with anti-inflammatory, anti-immune and anti-fibrotic functions. This study aimed at evaluating the relationship between allele polymorphisms in the IL-10 promoter region and hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.</p><p><b>METHODS</b>The odds ratios (ORs) of IL-10 allele distributions in patients with HBV or HCV infection were analyzed against healthy controls. All the relevant studies in PubMed were identified, and poor qualified studies were excluded. The meta-analysis software REVMAN 4.2 was applied for investigating heterogeneity among individual studies and summarizing all the studies. The publication bias was also evaluated.</p><p><b>RESULTS</b>This study demonstrated a significant association between the IL-10-592 A/C polymorphism and HBV infection in the Asian population under the overall effect size of allele A versus C. In our subgroup meta-analysis, we found a significant association of IL-10-592 A/C polymorphism to HCV infection susceptibility in Asian populations, although sensitivity analysis showed that the combined result was not associated with the worldwide population. Other IL-10 allele polymorphisms were not associated with HBV or HCV infection.</p><p><b>CONCLUSION</b>IL-10-592 A/C allele might be a risk factor for HBV or HCV in Asians but not in Europeans.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Epidemiology
/
Promoter Regions, Genetic
/
Interleukin-10
/
Hepatitis C
/
Genetic Predisposition to Disease
/
Alleles
/
Genetics
/
Hepatitis B
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2010
Type:
Article
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