Comparative studies of vasodilating effects of angiotensin-(1-7) on the different vessels / 生理学报
Acta Physiologica Sinica
; (6): 730-734, 2004.
Article
in En
| WPRIM
| ID: wpr-352706
Responsible library:
WPRO
ABSTRACT
The purpose of this study was to compare the vasodilating effects of angiotensin-(1-7) [Ang-(1-7)] on the different vessels and to clarify its mechanisms by using relaxing responses of preconstricted vascular rings. The results showed: (1) Ang-(1-7) dose-dependently induced vasorelaxation in all the vessels studied. However, there is apparent heterogeneity in the responsiveness of vessels from different origin. (2) The Ang-(1-7)-induced vasorelaxation was endothelium dependent and largely mediated by NO system. (3) The vasodilator action of Ang-(1-7) was not mediated by AT1 or AT2 receptor subtypes. It is suggested that the Ang-(1-7)-induced vasorelaxation is endothelium dependent by some other unclarified angiotensin receptor subtypes and is largely mediated by NO system.
Full text:
1
Index:
WPRIM
Main subject:
Peptide Fragments
/
Pharmacology
/
Physiology
/
Vasodilator Agents
/
Angiotensin I
/
Endothelium, Vascular
/
Receptor, Angiotensin, Type 1
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Metabolism
/
Nitric Oxide
Limits:
Animals
Language:
En
Journal:
Acta Physiologica Sinica
Year:
2004
Type:
Article