Baroreceptor reflex in heart failure / 生理学报
Acta Physiologica Sinica
;
(6): 269-281, 2004.
Article
in English
| WPRIM
| ID: wpr-352781
ABSTRACT
Congestive heart failure is a syndrome that is usually initiated by a reduction in pump function of the heart, i.e. a decrease in cardiac output. Initially, a reduction in cardiac output leads to unloading of baroreceptor reflex that, in turn, increases heart rate through vago-sympathetic mechanisms and total peripheral resistance via an increase in sympathetic outflow to vascular beds. In this review we are thinking on how baroreceptor reflex plays a role in the abnormal control of the circulation in heart failure. This review and our recent studies suggest that (1) baroreceptor reflex is blunted in heart failure; (2) central angiotensin II and reactive oxygen species play an important role in blunted baroreceptor reflex; (3) cardiac sympathetic afferent stimulation and chemoreceptor reflex inhibit baroreceptor reflex; and (4) exercise training normalizes abnormal reflexes in the heart failure state.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Sympathetic Nervous System
/
Vascular Resistance
/
Angiotensin II
/
Cardiac Output
/
Exercise
/
Chemoreceptor Cells
/
Reactive Oxygen Species
/
Baroreflex
/
Heart Failure
Limits:
Animals
/
Humans
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2004
Type:
Article
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