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Antagonistic effect of microwave on hematopoietic damage of mice induced by gamma-ray irradiation / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases ; (12): 525-529, 2009.
Article in Chinese | WPRIM | ID: wpr-352837
ABSTRACT
<p><b>OBJECTIVE</b>To investigate antagonistic effect of microwave on hematopoietic damage of mice induced by gamma-ray irradiation.</p><p><b>METHODS</b>Male healthy Kunning mice were treated with low dose microwave radiation before exposure to (60)Co gamma-ray irradiation of 8.0 Gy. The 30-day survival rate and average survival time of the mice after the treatment were examined. Peripheral blood parameters and the organ indexes of thymus and spleen were also observed in the irradiated mice. After exposure to 5.0 Gy gamma irradiation, indexes of hematopoietic foci formation of bone marrow cells (CFU-GM) and the proliferation activity of BMNCs were examined. The serum concentration of hemopoietic factors (GM-CSF and IL-3) were detected by ELISA kits.</p><p><b>RESULTS</b>Pre-exposure with 120 microW/cm(2) 900 MHz microwave increased the 30-day survival rate (P < 0.05) and the number of white blood cells of gamma-ray treated mice. The increases of the organ indexes of thymus and spleen, proliferation activity of BMNCs and CFU-GM hematopoietic foci numbers, as well as the higher serum concentration of GM-CSF and IL-3 were observed in the microwave pre-exposure group.</p><p><b>CONCLUSION</b>Low dose microwave radiation may exert potential antagonistic effects on hematopoietic injuries induced by ionizing radiation. The underlying mechanisms might be related with stimulation of hematopoietic growth factors expression, promotion of HSCs/HPCs proliferation, suppression on the reduction of HSCs/HPCs caused by (60)Co gamma-ray, and enhanced construction of the hematopoietic system.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Radiation Effects / Radiation Injuries, Experimental / Blood / Bone Marrow / Bone Marrow Cells / Cell Differentiation / Granulocyte-Macrophage Colony-Stimulating Factor / Interleukin-3 / Cell Proliferation Limits: Animals Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Radiation Effects / Radiation Injuries, Experimental / Blood / Bone Marrow / Bone Marrow Cells / Cell Differentiation / Granulocyte-Macrophage Colony-Stimulating Factor / Interleukin-3 / Cell Proliferation Limits: Animals Language: Chinese Journal: Chinese Journal of Industrial Hygiene and Occupational Diseases Year: 2009 Type: Article