TAR DNA binding protein-43 and fused in sarcoma/translocated in liposarcoma protein in two neurodegenerative diseases / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 286-292, 2012.
Article
in English
| WPRIM
| ID: wpr-352913
ABSTRACT
TAR DNA binding protein-43(TDP-43) and fused in sarcoma/translocated in liposarcoma protein (FUS/TLS) have been found to be associated with two neurodegenerative diseases - amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in TDP-43 and FUS/TLS lead to abnormal protein expressions, which result in altered RNA processing. The pathological changes of TDP-43 and FUS/TLS-associated ALS and FTD are similar. Although the interactions between ALS and FTD remain unknown, it is speculated that TDP-43 and FUS/TLS-associated neurodegenerative diseases may share similar pathogenesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA Processing, Post-Transcriptional
/
RNA-Binding Protein FUS
/
DNA-Binding Proteins
/
Frontotemporal Dementia
/
Genetics
/
Amyotrophic Lateral Sclerosis
/
Metabolism
/
Mutation
Limits:
Humans
Language:
English
Journal:
Acta Academiae Medicinae Sinicae
Year:
2012
Type:
Article
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