Research advances in suppressor of cytokine signaling 3 / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 178-182, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-352931
ABSTRACT
Suppressor of cytokine signaling(SOCS) 3, a novel type of cytokine signal transduction inhibitory molecules in family of SOCS, is mainly involved in Janus protein tyrosine kinase/signal transducer andantivator of transcription signaling pathway negative feedback regulation. It is involved in inflammation, oxidative stress, cell damage, and apoptosis. Meanwhile, it is closely related to atherosclerosis, obesity, glucose metabolism, insulin resistance, leptin, cancer, asthma, and rheumatic diseases. Therefore, SOCS-3 may become a therapeutic target of these diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Suppressor of Cytokine Signaling Proteins
/
Suppressor of Cytokine Signaling 3 Protein
Limits:
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2012
Type:
Article
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