Cell reprogramming: control key genes to obtain needed cells / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 689-695, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-352962
ABSTRACT
Cell reprogramming is a progress in which the memory of a mature cell is erased and then the cell develops novel phenotype and function; ultimately, the fate of the cell changes. Cell reprogramming usually occurs at genes expression levels that no genomic DNA sequence change will be involved. By changing the programs of the genetic expressions of cells in terms of space and time, cell reprogramming alters the differentiation of cells and thus produces the required cells. Further research on cells reprogramming will elucidate the mechanisms that govern the cell development, and thus provides more information of the sources of seed cells used for regeneration medicine. More cells differentiated from many terminally differentiated cells will be obtained, which is extremely important for the understanding of molecular differentiation and for the development of cell replacement therapy. This article summarizes the classification, influencing factors, approaches and latest advances of cells reprogramming.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Gene Expression
/
Cell Differentiation
/
Nuclear Transfer Techniques
/
Cellular Reprogramming
/
Cell Dedifferentiation
/
Genetics
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Academiae Medicinae Sinicae
Year:
2011
Type:
Article
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