Whole-genome sequencing on one case of Han familial keloids / 中华整形外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To screen SNP information of keloid pedigrees through whole genome sequencing.</p><p><b>METHODS</b>We Collected information and clinical data of the keloid pedigree and constructed charts of the pedigree. The DNA was extracted from peripheral venous blood samples of the pedigree to sequence the whole genome.</p><p><b>RESULTS</b>27 SNP and 8 disease-associated genes were screened out.</p><p><b>CONCLUSIONS</b>Whole genome sequencing technology can select new genetic mutations associated with keloid, and provide a new way for the research of keloid.</p>