Effect on synthesis of nitric oxide in myocardium by local cryoablation / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 77-84, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-353244
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect on synthesis of nitric oxide in myocardium by local cryoablation and to investigate its mechanism.</p><p><b>METHODS</b>Myocardium was cryoablated locally by a probe cooled to -60 degrees C and rewarmed by normal salt solution, nitric oxide and its synthesis enzyme were measured before and after cryoablation. L-arginine or methylene blue was added before and during cryoablation and the effect of these drugs on synthesis of nitric oxide was studied.</p><p><b>RESULTS</b>Nitric oxide and its synthesis enzyme decreased after cryoablation; L-arginine preserved the synthesis of nitric oxide and methylene blue inhibited the synthesis of nitric oxide. However, nitric oxide in serum did not change.</p><p><b>CONCLUSION</b>Nitric oxide and its synthesis enzyme in myocardium decrease after cryoablation.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Nitric Oxide Synthase
/
Cryosurgery
/
Metabolism
/
Myocardium
/
Nitric Oxide
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2005
Type:
Article
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