Therapeutic effect of cationic liposome-mediated interleukin-12 gene delivery on murine melanoma in vivo / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 73-76, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-353245
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the therapeutic effect of cationic liposome-mediated interleukin-12 gene delivery on established murine melanoma in vivo.</p><p><b>METHODS</b>The lipofectin encapsulated pCmIL-12 plasmid was given to C57BL/6 mice on the day 3,5,7,9 after inoculation of B16 melanoma cells. The tumor size, the survival time of mice and the NK cell activity were observed.</p><p><b>RESULTS</b>The pCmIL-12 plasmid coupled with cationic liposome inhibited the tumor growth and improved the survival of mice bearing established melanoma. The activity of NK cells was also enhanced after interleukin-12 gene delivery in vivo.</p><p><b>CONCLUSION</b>Cationic liposome-mediated interleukin-12 gene delivery has significantly therapeutic effects on mice melanoma in vivo.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Therapeutics
/
Melanoma, Experimental
/
DNA
/
Tumor Cells, Cultured
/
Killer Cells, Natural
/
Cations
/
Interleukin-12
/
Therapeutic Uses
/
Allergy and Immunology
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2005
Type:
Article
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